Abstract
The action of reduced iron on solutions of nitro ketones of the thiophene series in a mixture of acetic acid and acetic anhydride gave the corresponding acetamido ketones, which can be used, for example, for the synthesis of diacetamidothiophenes (through the oximes).
Similar content being viewed by others
Literature cited
K. Gewald, Khim. Geterotsikl. Soedin., No. 10, 1299 (1976).
D. Binder, G. Habison, and Ch. R. Noe, Synthesis, No. 4, 255 (1977).
C. Gavler and F. Garcia, J. Heterocycl. Chem., 18, 851 (1981).
O. Meth-Cohn and B. Narine, Synthesis, No. 2, 133 (1980).
Ya. L. Gol'dfarb, M. M. Polonskaya, B. P. Fabrichnyi, and I. F. Shalavina, Dokl. Akad. Nauk SSSR, 126, 86 (1956).
J. Cymmerman-Creig and D. Willis, J. Chem. Soc., No. 4, 1071 (1955).
L. H. Klemm, R. Zell, I. T. Barnisch, R. A. Klemm, C. E. Klopfenstein, and D. R. McCoy, J. Heterocycl. Chem., 7, 373 (1970).
L. H. Klemm and W. Hsin, J. Heterocycl. Chem., 12, 1183 (1975).
A. B. Sen and P. M. Bharagava, J. Indian Chem. Soc., 26, No. 2, 71 (1949).
M. Kohn and O. Krasso, J. Org. Chem., 13, 329 (1942).
W. Steinkopf and D. Jaffe, Annalen, 413, 333 (1917).
B. M. de Malleray, Helv. Chim. Acta, 54, 353 (1971).
B. P. Fabrichnyi, S. M. Kostrova, G. P. Gromova, and Ya. L. Gol'dfarb, Khim. Geterotsikl. Soedin., No. 11, 1483 (1973).
Ch. M. Asprou, J. S. A. Brunskill, and H. Jeffrey, J. Heterocycl. Chem., 17, 87 (1980).
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1323–1325, October, 1982.
Rights and permissions
About this article
Cite this article
Gol'dfarb, Y.L., Fabrichnyi, B.P. & Shalavina, I.F. Reductive acetylation of nitro ketones of the thiophene series. Chem Heterocycl Compd 18, 1018–1020 (1982). https://doi.org/10.1007/BF00503182
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00503182