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Catalytic synthesis of dihydrofurans (review)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Various methods for the preparation of 2,3-dihydrofuran, 2,5-dihydrofuran, 2-methylenetetrahydrofuran, and their alkyl and aryl derivatives are examined. The most promising method for the preparation of 2,3-dihydrofuran is the conversion of 1,4-butanediol on cobalt catalysts. 2,5-Dihydrofuran is obtained by dehydration of 2-butene-1,4-diol on Al2O3, cobalt-containing and other catalysts, while 2-methylenetetrahydrofuran is obtained by dehydrohalogenation of tetrahydrofurfuryl halides. The various methods for the isomerization of 2,5-dihydrofuran to 2,3-dihydrofuran are discussed. Examples of the application of dihydrofurans in organic synthesis are presented.

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    V. A. Slavinskaya, R. A. Karakhanov, L. Yu. Brezhnev, I. I. Geiman, L. F. Bulenkova & A. K. Strautinya

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  1. V. A. Slavinskaya
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  2. R. A. Karakhanov
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  3. L. Yu. Brezhnev
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  4. I. I. Geiman
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  5. L. F. Bulenkova
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  6. A. K. Strautinya
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1299–1311, October, 1982.

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Slavinskaya, V.A., Karakhanov, R.A., Brezhnev, L.Y. et al. Catalytic synthesis of dihydrofurans (review). Chem Heterocycl Compd 18, 997–1008 (1982). https://doi.org/10.1007/BF00503178

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