Abstract
Reaction of 2-chlorophenothiazine with acryloyl and methacryloyl chloride, and dehydrochlorination of 10-(β-chloropropionyl)-2-chlorophenothiazine, has given 10-acryloyl- and 10-methacryloyl-2-chlorophenothiazine. The latter reacts with secondary amines to give chloracisin and its analogs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
M. D. Mashkovskii, Medicinal Substances [in Russian], Meditsina, Moscow, 1964.
French patent no. 2557;C. A., 61, 9507, 1964.
S. V. Zhuravlev and A. N. Gritsenko, ZhOKh, 26, 3385, 1956.
A. N. Gritsenko and S. V. Zhuravlev, ZhOKh, 30, 2640, 1960.
A. N. Gritsenko and S. V. Zhuravlev, Uch. Zap. Inst. farm. i khimoter., 1, 13, 1958.
E. Anderson, G. Bellinzona, P. Graig, G. Jaffe, K. Janeway, C. Keiser, and B. Lester, Arzneim.-Forsch., 12, 937, 1962.
L. Toldy, J. Borsy, M. Fekete, and B. Dumbovich, Hungarian patent no. 151102; C. A., 60, 12025, 1964.
O. M. Lerner, USSR patent no. 198342; Byull. izobr., no. 14, 20, 1967.
G. Stempel, R. Cross, and R. Mariella, J. Am. Chem. Soc., 72, 2299, 1950.
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, Vol. 6, No. 5, pp. 601–604, May, 1970.
Rights and permissions
About this article
Cite this article
Lerner, O.M. The synthesis of chloracisin analogs. Chem Heterocycl Compd 6, 554–556 (1970). https://doi.org/10.1007/BF00500671
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00500671