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Functional derivatives of thiophene

XIV. Alkylaminomethylation of α-acylamnothiophenes and synthesis of 1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The Mannich reaction with primary amines is a convenient method for the synthesis of β-acylaminomethyl derivatives of α-acylaminothiophenes, which are readily cyclized to substituted 1,2,3,4-tetrahydrothieno[2,3-d]pyrimidenes by the action of formaldehyde.

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Literature cited

  1. V. I. Shvedov, Yu. I. Trofimkin, V. K. Vasil'eva, T. F. Vlasova, and A. N. Grinev, Khim. Geterotsikl. Soedin., 914 (1975).

  2. V. I. Shvedov, I. A. Kharizomenova, and A. N. Grinev, Khim. Geterotsikl. Soedin., 1624 (1973).

  3. H. Möhrle and P. Spillman, Tetrahedron, 25, 5595 (1969).

    Google Scholar 

  4. M. Bush, J. prakt. Chem., 53, 414 (1896).

    Google Scholar 

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow

    V. I. Shvedov, I. A. Kharizomenova, N. V. Medvedeva & A. N. Grinev

Authors
  1. V. I. Shvedov
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  2. I. A. Kharizomenova
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  3. N. V. Medvedeva
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  4. A. N. Grinev
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Additional information

See [1] for communication XIII.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 918–920, July, 1975.

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Shvedov, V.I., Kharizomenova, I.A., Medvedeva, N.V. et al. Functional derivatives of thiophene. Chem Heterocycl Compd 11, 805–806 (1975). https://doi.org/10.1007/BF00497299

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  • DOI: https://doi.org/10.1007/BF00497299

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