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IgG-subclass concentrations in cord sera from premature, full term and small-for-dates babies

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Abstract

IgG-subclass concentrations were determined in cord sera from 47 premature, 59 full-term, and 29 small-for-dates babies of varying gestational age. In premature and full term babies the relative percentages of all four subclasses were in the range for normal adult values. However, in small-fordates babies significantly lowered IgG1-levels were found.

Zusammenfassung

Bei 47 Früh-, 59 Reif- und 29 Mangelgeborenen unterschiedlichen Gestationsalters wurde der IgG-Unterklassengehalt des Nabelschnurserums bestimmt. Bei Früh- und Reifgeborenen lagen die Konzentrationen aller vier Subklassen im Bereich normaler Erwachsenenwerte, bei Mangelgeborenen fanden sich signifikant erniedrigte IgG1-Spiegel.

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References

  • Allansmith, M., McClellan, B., Butterworth, M., Maloney, J.: The development of immunoglobulin levels in man. J. Pediatrics 72, 276 (1968)

    Google Scholar 

  • Battaglia, F., Lubchenco, L.: A practical classification of newborn infants by weight and gestational age. J. Pediatrics 71, 159 (1967)

    Google Scholar 

  • Berg, T.: Immunoglobulin levels in infants with low birth weights. Acta paediat. scand. 57, 369 (1968)

    Google Scholar 

  • Berg, T., Nilsson, B.: The foetal development of serum levels of IgG and IgM. Acta paediat. scand. 58, 577 (1969)

    Google Scholar 

  • Corrodi, U., Hitzig, W.: Die pränatale Entwicklung der Immunglobuline. Mschr. Kinderheilk. 121, 1 (1973)

    Google Scholar 

  • Gitlin, D., Koch, C.: On the mechanisms of maternofetal transfer of human albumin and γ-globulin in the mouse. J. clin. Invest. 47, 1204 (1969)

    Google Scholar 

  • Gitlin, D., Kumate, J., Urrusti, J., Morales, C.: The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. J. clin. Invest. 43, 1938 (1964)

    Google Scholar 

  • Hay, F., Hull, M., Torrigiani, G.: The transfer of human IgG subclasses from mother to foetus. Clin. Exp. Immunol. 9, 355 (1971)

    Google Scholar 

  • Hobbs, J., Davis, J.: Serum γG-globulin levels and gestational age in premature babies. Lancet 1967I, 757

  • Hohenauer, L.: Pränatale Dystrophie. Klin. Pädiat. 184, 433 (1972)

    Google Scholar 

  • Hyvarinen, M., Zeltzer, P., Oh, W., Stiehm, E.: Influence of gestational age on serum levels of alpha-1 fetoprotein, IgG globulin, and albumin in newborn infants. J. Pediatrics 82, 430 (1973)

    Google Scholar 

  • Kohler, P., Farr, R.: Elevation of cord over maternal IgG immunoglobulin: Evidence for an active placental IgG transport. Nature (Lond.) 210, 1070 (1966)

    Google Scholar 

  • Mancini, G., Carbonara, A., Heremans, J.: Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2, 235 (1965)

    Google Scholar 

  • Messner, R., Jelinek, J.: Receptors for human γG globulin on human neutrophils. J. clin. Invest. 49, 2165 (1970)

    Google Scholar 

  • Morell, A., Skvaril, F., Hitzig, W., Barandun, S.: IgG subclasses: development of the serum concentrations in ‘normal’ infants and children. J. Pediatrics 80, 960 (1972)

    Google Scholar 

  • Morell, A., Skvaril, F., Loghem, E. van, Kleemola, H.: Human IgG subclasses in maternal and fetal serum. Vox. Sang. 21, 481 (1971)

    Google Scholar 

  • Morphis, L., Gitlin, D.: Maturation of the maternofoetal transport system for human γ-globulin in the mouse. Nature (Lond.) 228, 573 (1970)

    Google Scholar 

  • Newman, S., Waldo, B., Johnston, R.: Separation of serum bactericidal and opsonizing activities for Haemophilus influenzae type b. Infection and Immunity 8, 488 (1973)

    Google Scholar 

  • Papadatos, C., Papaevanglou, G., Alexiou, D., Mendris, J.: Serum immunoglobulin G levels in small-for-date newborn babies. Arch. Dis. Childh. 45, 570 (1970)

    Google Scholar 

  • Quie, P., Messner, R., Williams, R.: Phagocytosis in subacute bacterial endocarditis. Localization of the primary opsonic site to the Fc fragment. J. exp. Med. 128, 553 (1968)

    Google Scholar 

  • Schur, P.: Human Gamma-G subclasses. In: Schwartz, R., Progress in clinical immunology, vol. 1. New York-London: Grune and Stratton 1972

    Google Scholar 

  • Schur, P., Alpert, E., Alper, Ch.: Gamma G subgroups in human fetal cord and maternal sera. Clin. Immunol. Immunopathol. 2, 62 (1973)

    Google Scholar 

  • Shakib, F., Stanworth, D., Drew, R., Catty, D.: A quantitative study of the distribution of IgG sub-classes in a group of normal human sera. J. Imm. Methods 8, 17 (1975)

    Google Scholar 

  • Thompson, F., Puritz, E., Kraus, S., Yount, W.: γG sub-classes of fluorescent treponemal antibodies (FTA). Correlation with complement fixation and clinical stage. Clin. Res. 21, 59 (1973)

    Google Scholar 

  • Virella, G., De Pascale, A., Lippi, U.: Placental transfer of a human IgG2 monoclonal protein. Experientia 27, 324 (1971)

    Google Scholar 

  • Wang, A., Faulk, W., Stuckey, M., Fudenberg, H.: Chemical differences of adult, fetal and hypogammaglobulinemic IgG immunoglobulin. Immunochemistry 7, 703 (1970)

    Google Scholar 

  • Yeung, C., Hobbs, J.: Serum-γG-globulin levels in normal, premature, post-mature and ‘smallfor-date’ newborn babies. Lancet 1, 1167 (1968)

    Google Scholar 

  • Yount, W., Darner, M., Kunkel, H., Kabat, E.: Studies on human antibodies VI. Selective variations in subgroup composition and genetic markers. J. exp. Med. 127, 633 (1968)

    Google Scholar 

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Catty, D., Seger, R., Drew, R. et al. IgG-subclass concentrations in cord sera from premature, full term and small-for-dates babies. Eur J Pediatr 125, 89–96 (1977). https://doi.org/10.1007/BF00489982

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  • DOI: https://doi.org/10.1007/BF00489982

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