Abstract
IgG-subclass concentrations were determined in cord sera from 47 premature, 59 full-term, and 29 small-for-dates babies of varying gestational age. In premature and full term babies the relative percentages of all four subclasses were in the range for normal adult values. However, in small-fordates babies significantly lowered IgG1-levels were found.
Zusammenfassung
Bei 47 Früh-, 59 Reif- und 29 Mangelgeborenen unterschiedlichen Gestationsalters wurde der IgG-Unterklassengehalt des Nabelschnurserums bestimmt. Bei Früh- und Reifgeborenen lagen die Konzentrationen aller vier Subklassen im Bereich normaler Erwachsenenwerte, bei Mangelgeborenen fanden sich signifikant erniedrigte IgG1-Spiegel.
Similar content being viewed by others
References
Allansmith, M., McClellan, B., Butterworth, M., Maloney, J.: The development of immunoglobulin levels in man. J. Pediatrics 72, 276 (1968)
Battaglia, F., Lubchenco, L.: A practical classification of newborn infants by weight and gestational age. J. Pediatrics 71, 159 (1967)
Berg, T.: Immunoglobulin levels in infants with low birth weights. Acta paediat. scand. 57, 369 (1968)
Berg, T., Nilsson, B.: The foetal development of serum levels of IgG and IgM. Acta paediat. scand. 58, 577 (1969)
Corrodi, U., Hitzig, W.: Die pränatale Entwicklung der Immunglobuline. Mschr. Kinderheilk. 121, 1 (1973)
Gitlin, D., Koch, C.: On the mechanisms of maternofetal transfer of human albumin and γ-globulin in the mouse. J. clin. Invest. 47, 1204 (1969)
Gitlin, D., Kumate, J., Urrusti, J., Morales, C.: The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. J. clin. Invest. 43, 1938 (1964)
Hay, F., Hull, M., Torrigiani, G.: The transfer of human IgG subclasses from mother to foetus. Clin. Exp. Immunol. 9, 355 (1971)
Hobbs, J., Davis, J.: Serum γG-globulin levels and gestational age in premature babies. Lancet 1967I, 757
Hohenauer, L.: Pränatale Dystrophie. Klin. Pädiat. 184, 433 (1972)
Hyvarinen, M., Zeltzer, P., Oh, W., Stiehm, E.: Influence of gestational age on serum levels of alpha-1 fetoprotein, IgG globulin, and albumin in newborn infants. J. Pediatrics 82, 430 (1973)
Kohler, P., Farr, R.: Elevation of cord over maternal IgG immunoglobulin: Evidence for an active placental IgG transport. Nature (Lond.) 210, 1070 (1966)
Mancini, G., Carbonara, A., Heremans, J.: Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2, 235 (1965)
Messner, R., Jelinek, J.: Receptors for human γG globulin on human neutrophils. J. clin. Invest. 49, 2165 (1970)
Morell, A., Skvaril, F., Hitzig, W., Barandun, S.: IgG subclasses: development of the serum concentrations in ‘normal’ infants and children. J. Pediatrics 80, 960 (1972)
Morell, A., Skvaril, F., Loghem, E. van, Kleemola, H.: Human IgG subclasses in maternal and fetal serum. Vox. Sang. 21, 481 (1971)
Morphis, L., Gitlin, D.: Maturation of the maternofoetal transport system for human γ-globulin in the mouse. Nature (Lond.) 228, 573 (1970)
Newman, S., Waldo, B., Johnston, R.: Separation of serum bactericidal and opsonizing activities for Haemophilus influenzae type b. Infection and Immunity 8, 488 (1973)
Papadatos, C., Papaevanglou, G., Alexiou, D., Mendris, J.: Serum immunoglobulin G levels in small-for-date newborn babies. Arch. Dis. Childh. 45, 570 (1970)
Quie, P., Messner, R., Williams, R.: Phagocytosis in subacute bacterial endocarditis. Localization of the primary opsonic site to the Fc fragment. J. exp. Med. 128, 553 (1968)
Schur, P.: Human Gamma-G subclasses. In: Schwartz, R., Progress in clinical immunology, vol. 1. New York-London: Grune and Stratton 1972
Schur, P., Alpert, E., Alper, Ch.: Gamma G subgroups in human fetal cord and maternal sera. Clin. Immunol. Immunopathol. 2, 62 (1973)
Shakib, F., Stanworth, D., Drew, R., Catty, D.: A quantitative study of the distribution of IgG sub-classes in a group of normal human sera. J. Imm. Methods 8, 17 (1975)
Thompson, F., Puritz, E., Kraus, S., Yount, W.: γG sub-classes of fluorescent treponemal antibodies (FTA). Correlation with complement fixation and clinical stage. Clin. Res. 21, 59 (1973)
Virella, G., De Pascale, A., Lippi, U.: Placental transfer of a human IgG2 monoclonal protein. Experientia 27, 324 (1971)
Wang, A., Faulk, W., Stuckey, M., Fudenberg, H.: Chemical differences of adult, fetal and hypogammaglobulinemic IgG immunoglobulin. Immunochemistry 7, 703 (1970)
Yeung, C., Hobbs, J.: Serum-γG-globulin levels in normal, premature, post-mature and ‘smallfor-date’ newborn babies. Lancet 1, 1167 (1968)
Yount, W., Darner, M., Kunkel, H., Kabat, E.: Studies on human antibodies VI. Selective variations in subgroup composition and genetic markers. J. exp. Med. 127, 633 (1968)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Catty, D., Seger, R., Drew, R. et al. IgG-subclass concentrations in cord sera from premature, full term and small-for-dates babies. Eur J Pediatr 125, 89–96 (1977). https://doi.org/10.1007/BF00489982
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00489982