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Improvement of vacuum nebulizing interface for direct coupling micro-liquid chromatograph with mass spectrometer and some applications to polar natural organic compounds

Verbesserung eines Vakuumzerstäubers als Zwischenstück zur direkten Kopplung von Mikro-Flüssig-Chromatograph und Massenspektrometer. Anwendung auf polare organische Verbindungen

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Zusammenfassung

Ein Vakuumzerstäuber wurde durch Einführung eines Wasser-Kühlmantels und einer Sättigungsvorrichtung für das Zerstäubergas verbessert. Dadurch konnte die Anwendbarkeit des Systems auf verschiedenartige nichtflüchtige polare organische Verbindungen (u. a. Adenosin, Tryptophan, Glycyl-glycyl-glycin, Mono- und Disaccharide) ausgedehnt werden. Das optimale Temperaturprofil und die Zerstäuberspitze wurde ebenfalls untersucht.

Summary

A vacuum nebulizing interface for direct coupling a micro-liquid chromatograph (LC) with a mass spectrometer (MS) was improved by incorporating a small water cooling jacket and a bubble saturator for the nebulizing gas. By this improvement the applicability of the micro-LC-MS system was remarkably extended to various non-volatile polar organic compounds such as adenosine, tryptophane, glycyl-glycyl-glycine, mono- and di-saccharides, etc. The desirable temperature profile around the nebulizing tip was also discussed.

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References

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Authors and Affiliations

  1. Department of Synthetic Chemistry, Faculty of Engineering, Nagoya University, 464, Nagoya, Japan

    H. Yoshida, K. Matsumoto, K. Itoh & S. Tsuge

  2. School of Materials Science, Toyohashi University of Technology, 440, Toyohashi, Japan

    Y. Hirata

  3. JASCO, Ishikawa-cho, 2967-5 Hachioji, 192, Tokyo, Japan

    K. Mochizuki, N. Kokubun & Y. Yoshida

Authors
  1. H. Yoshida
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  2. K. Matsumoto
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  3. K. Itoh
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  4. S. Tsuge
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  5. Y. Hirata
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  6. K. Mochizuki
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  7. N. Kokubun
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  8. Y. Yoshida
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Yoshida, H., Matsumoto, K., Itoh, K. et al. Improvement of vacuum nebulizing interface for direct coupling micro-liquid chromatograph with mass spectrometer and some applications to polar natural organic compounds. Z. Anal. Chem. 311, 674–680 (1982). https://doi.org/10.1007/BF00488943

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  • DOI: https://doi.org/10.1007/BF00488943

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