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Investigation of benzimidazole derivatives

XXVIII. Synthesis of some 3-[2′-benzimidazolyl]isoxazoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The hydrochlorides of the corresponding 2-benzimidazolylmethylhydroxamoyl chlorides were synthesized by the chlorination of 1-methyl-2-formylbenzimidazole oxime and its 5-methyl and 5-nitro derivatives, and 2-benzimidazolylmethylnitrolic acids were obtained by nitration of the oximes. The products of these transformations react with acetylacetone and benzoylacetone in the presence of bases to give 1′,5′-substituted 3-[2-benzimidazolyl]-4-acyl-5-methylisoxazoles.

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Authors and Affiliations

  1. Rostov-on-Don State University, Rostov-on-Don

    E. B. Tsupak, N. K. Chub, A. M. Simonov & N. M. Miroshnichenko

Authors
  1. E. B. Tsupak
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  2. N. K. Chub
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  3. A. M. Simonov
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  4. N. M. Miroshnichenko
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Additional information

See [1] for communication XXVII.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 812–815, June, 1972.

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Tsupak, E.B., Chub, N.K., Simonov, A.M. et al. Investigation of benzimidazole derivatives. Chem Heterocycl Compd 8, 734–737 (1972). https://doi.org/10.1007/BF00487471

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  • DOI: https://doi.org/10.1007/BF00487471

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