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Basic hydrolysis of 3-acetoxy-7-bromo-5-(o-chlorophenyl)-1-ethoxycarbonylmethyl-1,2-dihydro-3H-1,4-benzadiazepin-2-one

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The selective basic hydrolysis of 3-acetoxy-7-bromo-5-(o-chlorophenyl)-1-ethoxycarbonylmethyl-1,2-dihydro-3H-1,4-benzdiazepin-2-one has been carried out, resulting in the sequential formation of 3-hydroxy-1-ethoxycarbonylmethyl-, 3-hydroxy-1-methoxycarbonylmethyl-, and 3-hydroxy-1-carboxymethyl derivatives. The structure of the 1-methoxycarbonylmethyl derivatives has been established by x-ray structural analysis.

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Authors and Affiliations

  1. A. V. Bogatskii Physical Chemical Institute, Academy of Sciences of the Ukrainian SSR, Odessa

    A. A. Mazurov, A. A. Dvorkin, Yu. A. Simonov & S. A. Andronati

  2. Institute of Applied Physics, Academy of Sciences of the Moldavian SSR, Kishinev

    A. A. Mazurov, A. A. Dvorkin, Yu. A. Simonov & S. A. Andronati

Authors
  1. A. A. Mazurov
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  2. A. A. Dvorkin
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  3. Yu. A. Simonov
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  4. S. A. Andronati
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 685–690, May, 1990.

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Mazurov, A.A., Dvorkin, A.A., Simonov, Y.A. et al. Basic hydrolysis of 3-acetoxy-7-bromo-5-(o-chlorophenyl)-1-ethoxycarbonylmethyl-1,2-dihydro-3H-1,4-benzadiazepin-2-one. Chem Heterocycl Compd 26, 582–587 (1990). https://doi.org/10.1007/BF00487438

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  • DOI: https://doi.org/10.1007/BF00487438

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