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Synthesis of 3-alkyl(aryl)-3-aminoquinuclidines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A series of 3-alkyl(aryl)-3-aminoquinuclidines was synthesized by means of the interaction between 3-alkyl(aryl)-3-oxyquinuclidines and acetonitrile in the presence of concentrated sulfuric acid with subsequent hydrolysis of the 3-alkyl(aryl)-3-acetaminoquinuclidines. It was shown that in addition to acetamino derivatives 3-alkyl-Δ2-dehydroquinuclidines and 3-alkylidenequinuclidines are formed, the structure of which was established by the method of NMR.

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References

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Authors and Affiliations

  1. Ordzhonikidze All-Union Chemical and Pharmaceutical Scientific-Research Institute, Moscow

    E. E. Mikhlina, V. Ya. Vorob'eva, K. F. Turchin & M. V. Rubtsov

Authors
  1. E. E. Mikhlina
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  2. V. Ya. Vorob'eva
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  3. K. F. Turchin
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  4. M. V. Rubtsov
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Mikhlina, E.E., Vorob'eva, V.Y., Turchin, K.F. et al. Synthesis of 3-alkyl(aryl)-3-aminoquinuclidines. Chem Heterocycl Compd 4, 787–790 (1968). https://doi.org/10.1007/BF00486962

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  • DOI: https://doi.org/10.1007/BF00486962

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