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Five-membered 2,3-dioxoheterocycles 3. The reaction of 5-aryl-2,3-dihydrofuran-2,3-diones with aliphatic and aromatic nitriles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

On reaction of 5-aryl-2,3-dihydrofuran-2,3-diones with α-aminoisobutyronitrile, o-aminobenzonitrile, and Β-anilinopropiononitrile, we obtained aroylpyruvic acid N-(1-methyl-1-cyanoethyl)-, N-(o-cyanophenyl)-, and N-phenyl-N-(cyanoethyl)-amides, respectively. On reaction of 5-aryl-2,3-dihydrofuran-2,3-diones with cyanoacetamide we obtained aroylacetic acid N-(cyanoacetyl)amides, while in the case of methyleneaminoacetonitrile and p-dimethylaminobenzonitrile we obtained (6-aryl-4-oxo-2,3-dihydro-1,3-oxazin-3-yl)acetonitriles and 2-(p-dimethylaminophenyl)-6-aryl-1,3-oxazine-4-ones, respectively.

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Authors and Affiliations

  1. Perm State Pharmaceutical Institute, 614600, Perm

    Yu. S. Andreichikov, D. D. Nekrasov, M. A. Rudenko & A. Yu. Konovalov

Authors
  1. Yu. S. Andreichikov
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  2. D. D. Nekrasov
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  3. M. A. Rudenko
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  4. A. Yu. Konovalov
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Additional information

For Communication 2, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 740–743, June, 1987.

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Andreichikov, Y.S., Nekrasov, D.D., Rudenko, M.A. et al. Five-membered 2,3-dioxoheterocycles 3. The reaction of 5-aryl-2,3-dihydrofuran-2,3-diones with aliphatic and aromatic nitriles. Chem Heterocycl Compd 23, 610–613 (1987). https://doi.org/10.1007/BF00486902

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  • DOI: https://doi.org/10.1007/BF00486902

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