Abstract
3-Ethoxycarbonyl- and 3-acetyl-4-cyano-2,4, 6, 6-tetramethyl-1, 4, 5, 6-tetrahydropyridines have been obtained by the reaction of diacetoneamine with acetoacetic ester (or acetylacetone), the conversion of the amino ketones so obtained into the corresponding cyanohydrins, and the cyclization of the latter under the influence of alkali.
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I. A. Zaitsev, M. M. Shestaeva, and V. A. Zagorevskii, USSR patent, no. 172804; Byull. izobr., no. 14, 1965.
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Zaitsev, I.A., Shestaeva, M.M., Zagorevskii, V.A. et al. A new synthesis of substituted 1,4,5,6-tetrahydropyridines. Chem Heterocycl Compd 4, 485–487 (1971). https://doi.org/10.1007/BF00486765
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DOI: https://doi.org/10.1007/BF00486765