Chemistry of Heterocyclic Compounds

, Volume 25, Issue 5, pp 535–540 | Cite as

Analogs of purine nucleosides. 4. 7-Alkylated 9-(2-hydeoxymethyl)guanine

  • M. A. Madre
  • R. A. Zhuk
  • M. Yu. Lidak


7,9-Disubstituted guaninium hydrohalides were synthesized by the reaction of 9- and 7-(2-hydroxymethyl)guanines with alkyl halides. The effect of the structure of the alkylating agent on the direction and yield of the alkylation reaction was established. The possibility of the conversion of the salts obtained to the free bases in a weakly alkaline medium was investigated. The synthesized compounds were characterized by the UV and 1H and 13C NMR spectra. The ability of the synthesized compounds to inhibit replication of the herpes virus (VPG-1) was demonstrated.


Organic Chemistry Alkylation Purine Nucleoside Guanine 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • M. A. Madre
    • 1
  • R. A. Zhuk
    • 1
  • M. Yu. Lidak
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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