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Chemistry of Heterocyclic Compounds

, Volume 25, Issue 5, pp 530–535 | Cite as

4-Methyl-5-hydroxypyrimidine and its N-oxides: Synthesis and investigation of the reactivities in electrophilic substitution

  • S. B. Gashev
  • L. V. Gol'tsova
  • L. D. Smirnov
  • V. P. Lezina
Article

Abstract

A new more accessible method for the synthesis of 4-methyl-5-hydroxypyrimidine is proposed; its 1- and 3-oxides were obtained. An attempt was made to evaluate the reactivities of the individual positions of the heterocyclic ring of pyrimidine and its 3-oxide in aminomethylation.

Keywords

Organic Chemistry Pyrimidine Heterocyclic Ring Individual Position Accessible Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • S. B. Gashev
    • 1
  • L. V. Gol'tsova
    • 1
  • L. D. Smirnov
    • 1
  • V. P. Lezina
    • 1
  1. 1.Institute of Chemical PhysicsAcademy of Sciences of the USSRMoscow

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