Abstract
A study is made of the effectiveness of Fischer catalysts (zinc chloride, cuprous chloride, boron trifluoride, polyphosphoric, hydrochloric, sulfosalicylic, and p-toluenesulfonic acid) for the cyclization of cyclohexanone pyridyl-2-hydrazone and 6-methylpyridyl-2-hydrazone. The great effectiveness of mineral and sulfonic acids as compared with Lewis acids is shown. The possibility is shown of changing the course of the process by introducing an electron-donating substituent into the pyridine ring. 1-Acetyl and 1-benzyl derivatives of α-carboline are synthesized.
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Yakhontov, L.N., Pronina, E.V. & Rubtsov, M.V. The problem of the relative effectiveness of fischer reaction catalysts. Chem Heterocycl Compd 3, 549–552 (1967). https://doi.org/10.1007/BF00481602
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DOI: https://doi.org/10.1007/BF00481602