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Methylation of pyrimidine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A mixture of isomers that differ with respect to the position of the methyl group is formed in the methylation of 5,5-diethyl-6-imino-5,6-dihydro[1H, 3H]pyrimidine-2,4-dione with excess methyl iodide in the presence of ethoxide. Isomerization of the Dimroth-rearrangement type was observed. The mass spectra of the isomers are examined, and the IR spectra of the tautomeric forms are discussed.

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Authors and Affiliations

  1. Branch of the S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, 142450, Kupavna, Moscow Oblast

    V. G. Voronin, S. B. Goncharenko, Yu. N. Portnov, A. I. Ermakov & M. I. Shemeryankina

Authors
  1. V. G. Voronin
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  2. S. B. Goncharenko
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  3. Yu. N. Portnov
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  4. A. I. Ermakov
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  5. M. I. Shemeryankina
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 823–826, June, 1978.

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Voronin, V.G., Goncharenko, S.B., Portnov, Y.N. et al. Methylation of pyrimidine derivatives. Chem Heterocycl Compd 14, 675–678 (1978). https://doi.org/10.1007/BF00481146

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  • DOI: https://doi.org/10.1007/BF00481146

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