Abstract
The halogenation of 2,3-dimethylpyrazino[2,3-b][1,4]thiazin-6-one with bromine or 1 mole of sulfuryl chloride gives 7-bromo-and 7-chloropyrazino[2,3-b][1,4]thiazin-6-ones, while 2 moles of sulfuryl chloride give 7,7-dichloropyrazino[2,3-b][1,4]thiazin-6-one. A number of 7-amino-and 7,7-diaminopyrazino[2,3-b][1,4]thiazin-6-ones were obtained by the reaction of the appropriate halo derivatives with amines. Some of the pyrazino[2,3-b][1,4]thiazin-6-one derivatives inhibit the growth of interweavable tumors in animals.
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T. S. Safonova, in: Modern State of the Chemotherapy of Malignant Tumors [in Russian], Riga (1968), p. 37.
T. S. Safonova and L. A. Myshkina, Khim. Geterotsikl. Soedin., No. 3, 232 (1971).
T. S. Safonova and L. G. Levkovskaya, Khim. Geterotsikl. Soedin., 78 (1971).
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See [3] for communication XX.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1498–1501, November, 1971.
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Safonova, T.S., Myshkina, L.A., Chernov, V.A. et al. Investigation of nitrogen- and sulfur-containing heterocyclic compounds. Chem Heterocycl Compd 7, 1393–1396 (1971). https://doi.org/10.1007/BF00481103
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DOI: https://doi.org/10.1007/BF00481103