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Researches on lactams

VIII. 3- Ethoxy-3, 4-dehydromorpholine and its condensation with aminocyanoacetamide and hydrazine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Replacement of the β-methylene group in O-alkylvalerolactim by an oxygen atom leaves the reactivity of the lactim group substantially unchanged. It is shown that the ability of simplest lactim ethers to undergo condensation with α-amino-α cyanoacetamide and hydrazine hydrate also extends to 3-ethoxy-3, 4-dehydromorpholine, making it possible to synthesize new heterocyclic systems (morpholinoimidazole, morpholinopurine, and morpholinotetrazole). Replacement of a methylene group in derivatives of tetramethylenimidazole, purine, and tetrazole by an oxygen atom, markedly decreases the biological activities of these compounds.

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References

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Authors and Affiliations

  1. Ordzhonikidze All-Union Pharmaceutical Chemistry, Scientific Research Institute, Moscow

    R. G. Glushkov & O. Yu. Magidson

Authors
  1. R. G. Glushkov
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  2. O. Yu. Magidson
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For Part VII see [1].

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Glushkov, R.G., Magidson, O.Y. Researches on lactams. Chem Heterocycl Compd 2, 134–137 (1967). https://doi.org/10.1007/BF00480955

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  • DOI: https://doi.org/10.1007/BF00480955

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