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3-carbamido-2-indolylurethanes and their cyclization to pyrimido[4,5-b] indoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of isocyanates and isothiocyanates with 2-indolylurethanes takes place primarily in the 3 position of the indole ring to give the corresponding amides and thioamides, which smoothly undergo cyclization when they are heated with sodium ethoxide to give the corresponding quinazoline derivatives.

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Authors and Affiliations

  1. Moscow State University, 117234, Moscow

    T. Jagodzinski, A. N. Kost & R. S. Sagitullin

  2. Szczecin Polytechnic Institute, Poland

    T. Jagodzinski, A. N. Kost & R. S. Sagitullin

Authors
  1. T. Jagodzinski
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  2. A. N. Kost
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  3. R. S. Sagitullin
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 214–223, February, 1979.

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Jagodzinski, T., Kost, A.N. & Sagitullin, R.S. 3-carbamido-2-indolylurethanes and their cyclization to pyrimido[4,5-b] indoles. Chem Heterocycl Compd 15, 179–187 (1979). https://doi.org/10.1007/BF00480364

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  • DOI: https://doi.org/10.1007/BF00480364

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