2-Carbomethoxyaminobenzimidazole in the synthesis of 2-oxo-1,2,3,4-tetrahydropyrimido-[1,2-a]benzimidazole and its derivatives
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A one-step method was developed for the preparation of 2-oxo-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole and its 3-methyl, 4-methyl, 4,4-dimethyl, and 4-phenyl derivatives by heating 2-carbomethoxyaminobenzimidazole with acrylic, methacrylic, crotonic, and cinnamic acids at 140–200°C. A possible scheme for the formation of the indicated compounds is presented.
KeywordsOrganic Chemistry Benzimidazole Cinnamic Acid
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