Chemistry of Heterocyclic Compounds

, Volume 13, Issue 10, pp 1114–1117 | Cite as

2-Carbomethoxyaminobenzimidazole in the synthesis of 2-oxo-1,2,3,4-tetrahydropyrimido-[1,2-a]benzimidazole and its derivatives

  • A. A. Shazhenov
  • Ch. Sh. Kadyrov


A one-step method was developed for the preparation of 2-oxo-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole and its 3-methyl, 4-methyl, 4,4-dimethyl, and 4-phenyl derivatives by heating 2-carbomethoxyaminobenzimidazole with acrylic, methacrylic, crotonic, and cinnamic acids at 140–200°C. A possible scheme for the formation of the indicated compounds is presented.


Organic Chemistry Benzimidazole Cinnamic Acid 
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Literature cited

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    Outline of the Chemistry of Azoles [in Russian], Izd. Rostovsk. Gosudarstv. Univ. (1965), p. 37.Google Scholar
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    N. K. Khakimova, A. A. Shazehnov, and Ch. Sh. Kadyrov, Dokl. Akad. Nauk Uzb. SSR, 6, 35 (1975).Google Scholar
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    C. I. Delp and H. L. Kloping, Plant Disease Rep., 52, No. 2, 95 (1968).Google Scholar
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    D. C. Erwin, H. Mee, and Y. Y. Sims, Phytopathology, 58, 528 (1968).Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • A. A. Shazhenov
    • 1
  • Ch. Sh. Kadyrov
    • 1
  1. 1.Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Uzbek SSRTashkent

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