Abstract
A number of O-(benzyloxycarbonylglycyl) derivatives of alkyl-, phenyl-, and pyridyl-substituted oximes were synthesized, and their chemical properties and reactivities under aminolysis conditions were studied. The principal factor that determines the reactivities of the investigated compounds during the formation of a peptide bond is the presence of a weakly acidic catalyst; the different reactivities of the compounds under the same conditions are due to the influence of the electron-acceptor effects of the substituents attached to the carbon atom of the oxime group.
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The authors thank the Polish Academy of Sciences for financial support (state subsidy MR 1.12.1.6.1.5).
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1336–1339, October, 1977.
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Romanovski, P.Y., Plucinski, T. & Kupryszewski, G. Synthesis and study of the rate of aminolysis of O-(acylaminoacyl)oximes of formylpyridines and pyridyl methyl ketones. Chem Heterocycl Compd 13, 1069–1072 (1977). https://doi.org/10.1007/BF00480138
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DOI: https://doi.org/10.1007/BF00480138