Chemistry of Heterocyclic Compounds

, Volume 13, Issue 10, pp 1069–1072 | Cite as

Synthesis and study of the rate of aminolysis of O-(acylaminoacyl)oximes of formylpyridines and pyridyl methyl ketones

  • P. Ya. Romanovski
  • T. Plucinski
  • G. Kupryszewski


A number of O-(benzyloxycarbonylglycyl) derivatives of alkyl-, phenyl-, and pyridyl-substituted oximes were synthesized, and their chemical properties and reactivities under aminolysis conditions were studied. The principal factor that determines the reactivities of the investigated compounds during the formation of a peptide bond is the presence of a weakly acidic catalyst; the different reactivities of the compounds under the same conditions are due to the influence of the electron-acceptor effects of the substituents attached to the carbon atom of the oxime group.


Peptide Methyl Organic Chemistry Phenyl Carbon Atom 
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • P. Ya. Romanovski
    • 1
    • 2
  • T. Plucinski
    • 1
    • 2
  • G. Kupryszewski
    • 1
    • 2
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga
  2. 2.Institute of ChemistryGdansk UniversityPoland

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