Abstract
Depending on the reagent ratio, 5-dimethylaminomethyl-4-imidazole-4-carboxylic acid and 2,4,5-tris(dimethylaminomethyl)imidazole were obtained in the aminomethylation of imidazole-4-carboxylic and imidazole-4,5-dicarboxylic acids. The oxidation of these compounds with nitric acid leads to imidazole-4,5-dicarboxylic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 206–208, February, 1989.
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Belyaev, N.A., Mokrushin, V.S. Carboxyimidazoles in the mannich reaction. Chem Heterocycl Compd 25, 165–168 (1989). https://doi.org/10.1007/BF00479911
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DOI: https://doi.org/10.1007/BF00479911