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Acylation of 2-aminoquinazol-4-ones by unsaturated acid chlorides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The acylation of 2-aminoquinazol-4-one by unsaturated acid chlorides proceeds principally at the exocyclic nitrogen atom and is complicated in the case of acryloyl chloride by a further intramolecular condensation forming 1,2,3,4-tetrahydropyrimido(2,1-b)quinazolin-2,6-dione. A lower acylation temperature using methacryloyl chloride leads to accumulation of 1-methacryloyl-2-aminoquinazol-4-one in the reaction mixture.

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Literature Cited

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Authors and Affiliations

  1. Leningrad Lensoviet Technological Institute, 198013, Leningrad

    L. M. Yun, K. O. Nazhimov, S. Masharipov, R. A. Samiev, S. A. Makhmudov, S. S. Kasymova, S. N. Vergizov, K. A. V'yunov & Kh. M. Shakhidoyatov

  2. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, 700170, Tashkent

    L. M. Yun, K. O. Nazhimov, S. Masharipov, R. A. Samiev, S. A. Makhmudov, S. S. Kasymova, S. N. Vergizov, K. A. V'yunov & Kh. M. Shakhidoyatov

  3. Tashkent Medical Institute, 700033, USSR

    L. M. Yun, K. O. Nazhimov, S. Masharipov, R. A. Samiev, S. A. Makhmudov, S. S. Kasymova, S. N. Vergizov, K. A. V'yunov & Kh. M. Shakhidoyatov

Authors
  1. L. M. Yun
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  2. K. O. Nazhimov
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  3. S. Masharipov
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  4. R. A. Samiev
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  5. S. A. Makhmudov
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  6. S. S. Kasymova
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  7. S. N. Vergizov
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  8. K. A. V'yunov
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  9. Kh. M. Shakhidoyatov
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1527–1531, November, 1987.

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Yun, L.M., Nazhimov, K.O., Masharipov, S. et al. Acylation of 2-aminoquinazol-4-ones by unsaturated acid chlorides. Chem Heterocycl Compd 23, 1222–1226 (1987). https://doi.org/10.1007/BF00479374

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  • DOI: https://doi.org/10.1007/BF00479374

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