Abstract
The chemical properties of 2-chloro-3-(β-chloroethyl)-4,6-dihydroxypyridine (I) have been studied. It has been shown that this compound, which is relatively stable in acids and in neutral and, particularly, in alkaline media, readily splits off hydrogen chloride under mild conditions and is converted into derivatives of 2, 3-dihydro-5-azabenzofuran. The dehalogenation of I in an acid medium yielded 3-(β-chloroethyl)-4, 6-dihydroxypyridine, which was converted into 4, 6-dichloro-3-(β-chloroethyl)pyridine and into 6-chloro-4-methoxy-3-vinylpyridine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. N. Yakhontov, M. Ya. Uritskaya, and M. V. Rubtsov, KhGS [Chemistry of Heterocyclic Compounds], 918, 1965.
S. J. Davis, J. A. Elvidge and A. B. Foster, J. Chem. Soc., 3638, 1962.
L. N. Yakhontov, E. I. Lapan, and M. V. Rubtsov, KhGS [Chemistry of Heterocyclic Compounds], 1063, 1967.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yakhontov, L.N., Uritskaya, M.Y., Lapan, E.I. et al. Some reactions of 2-chloro-3-(β-chloroethyl)-4,6-dihydroxypyridine. Chem Heterocycl Compd 4, 14–17 (1970). https://doi.org/10.1007/BF00478066
Issue Date:
DOI: https://doi.org/10.1007/BF00478066