Abstract
6-Phenylacetamido- and 6-phenoxyacetamidopenicillan-3 -acetic acids (“homopenicillins”) have been obtained from benzyl- and phenoxymethylpenicillins respectively, via their diazoketones. In these compounds, the carboxyl group is separated from the basic thiazolidine-β-lactam ring of the penicillins by a methylene group, The homopenicillins, which were characterized as their anilides, possess low antibacterial activity and are powerful penicillinase inducers.
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Kleiner, E.M., Senyavina, L.B. & Khokhlov, A.S. The preparation and properties of 6-phenylacetamido- and 6-phenoxyacetamidopenicillan-3-acetic acids (“homopenicillins”). Chem Heterocycl Compd 2, 538–540 (1966). https://doi.org/10.1007/BF00477514
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DOI: https://doi.org/10.1007/BF00477514