Abstract
Bromine, and, for the first time, iodine, are inserted at various positions in the 1, 3-oxazole ring by halogenating mercury derivatives of oxazole. Thus, unlike what is obtained by direct halogenation, halogen derivatives of oxazole are available independently of alkyl or phenyl substituents already present in the ring. Direct halogenation of phenyl-substituted oxazoles is reviewed, and in this connection 2, 4-diphenyloxazole is brominated directly. α-Bromo derivatives of 1, 3-oxazole are also synthesized.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
O. P. Shvaika and G. P. Klimisha. KhGS, 19, 1966.
R. Gompper and F. Effenberger, Angew. Chem. 70, 628, 1958.
R. Gompper and H. Rühle, Ann., 626, 83, 1959.
R. Gompper and H. Rühle, Ann., 626, 92, 1959.
C. Mossebois and F. Eloy, Helv. Chim. Acta., 47, 898, 1964.
O. P. Shvaika and G. P. Klimisha, DAN URSR, no. 11, 1479, 1965.
R. Robinson, J. Chem. Soc., 95, 2167, 1909.
E. Fischer, Ber., 29, 213, 1896.
N. Hayes, B. S. Rogers, and D. G. Otto, J. Am. Chem. Soc., 77, 1850, 1955.
Author information
Authors and Affiliations
Additional information
For Part I see [1].
Rights and permissions
About this article
Cite this article
Shvaika, O.P., Klimisha, G.P. Researches on oxazoles. Chem Heterocycl Compd 2, 517–520 (1966). https://doi.org/10.1007/BF00477508
Issue Date:
DOI: https://doi.org/10.1007/BF00477508