Abstract
3,5-Diarylisoxazoles in acetic acid are smoothly converted to 4-chloro derivatives by the action of chlorine in situ. A side reaction is subsequent addition of hypochlorous acid, which proceeds under the influence of excess chlorine. It is convenient to use tert-butyl hypochlorite for the chlorination of more reactive arylisoxazoles.
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See [1] for communication XXV.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1325–1328, October, 1973.
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Sokolov, S.D., Yudintseva, I.M. Research in the isoxazole series. Chem Heterocycl Compd 9, 1199–1201 (1973). https://doi.org/10.1007/BF00477447
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DOI: https://doi.org/10.1007/BF00477447