Chemistry of Heterocyclic Compounds

, Volume 8, Issue 4, pp 419–421 | Cite as

Dipole moments of some isoxazole derivatives

  • I. B. Mazheika
  • I. S. Yankovska
  • S. D. Sokolov
  • I. M. Yudintseva


The dipole moments of isoxazole and 13 of its halo, amino, and nitro derivatives were measured. A method is proposed for vector calculation for estimating the direction of the dipole moment of the isoxazole ring. It is demonstrated that phenyl substituents in the 3 and 5 positions are electron donors with respect to the isoxazole ring. It was found that the dipole moments of 4-substituted 3,5-dimethylisoxazoles correlate satisfactorily with the Hammett constants.


Organic Chemistry Phenyl Dipole Moment Electron Donor Isoxazole 
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Copyright information

© Consultants Bureau 1974

Authors and Affiliations

  • I. B. Mazheika
    • 1
    • 2
  • I. S. Yankovska
    • 1
    • 2
  • S. D. Sokolov
    • 1
    • 2
  • I. M. Yudintseva
    • 1
    • 2
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga
  2. 2.S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical ChemistryMoscow

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