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Research on imidazo[1,2-a] benzimidazole derivatives

XIV. α,β-Unsaturated ketones of the imidazo[1,2-a]benzimidazole series

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

α,β-Unsaturated ketones of the imidazo[1,2-a]benztmidazole series were synthesized from 3-formyl- and 3-acetyl-substituted imidazo[1,2-a]benzimidazoles by crotonic condensation in the presence of alkaline catalysts. The α,β-unsaturated ketones can also be obtained by direct acylation of 3-unsubstituted imidazo[1,2-a]benzimidazoles with the chlorides of unsaturated acids. The properties and pharmacological activity of the ketones obtained were studied.

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Authors and Affiliations

  1. Scientific-Research Institute of Physical and Organic Chemistry, Rostov State University, Rostov-on-Don

    V. A. Anisimova, N. I. Avdyunina, A. M. Simonov, G. V. Kovalev & S. M. Gofman

  2. Volgograd Medical Institute, USSR

    V. A. Anisimova, N. I. Avdyunina, A. M. Simonov, G. V. Kovalev & S. M. Gofman

Authors
  1. V. A. Anisimova
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  2. N. I. Avdyunina
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  3. A. M. Simonov
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  4. G. V. Kovalev
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  5. S. M. Gofman
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Additional information

See [1] for communication XIII.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1660–1665, December, 1976.

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Anisimova, V.A., Avdyunina, N.I., Simonov, A.M. et al. Research on imidazo[1,2-a] benzimidazole derivatives. Chem Heterocycl Compd 12, 1365–1369 (1976). https://doi.org/10.1007/BF00476729

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  • DOI: https://doi.org/10.1007/BF00476729

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