Abstract
By treating 8-aminotheophylline with hydroxylamine-O-sulfonic acid in aqueous alkali we have obtained 7,8-diaminotheophylline and studied its reactions with benzaldehyde, 1,2-dicarbonyl compounds, and acylating agents. We have established that in reactions with electrophiles, the N-amino group in 7,8-diaminotheophylline is more active than the amino group situated at the 8-position. An unexpected self-condensation of two molecules of 7,8-diaminotheophylline has been found in acid medium, leading to a purino[8,7-g]-7-azapteridine derivative.
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For Communication 2, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1398–1404, October, 1987.
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Nanavyan, I.M., Kuz'menko, V.V., Pozharskii, A.F. et al. Purines, pyrimidines, and condensed systems based on them. 3. 7,8-Diaminotheophylline. Chem Heterocycl Compd 23, 1123–1129 (1987). https://doi.org/10.1007/BF00476545
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DOI: https://doi.org/10.1007/BF00476545