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2,4-Dihydroxy-5,6-dihydropyrimidine derivatives

IV. Effect of the structure of amines on the formation of amides of dihydroorotic or ureidosuccinic acids

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of dihydroorotic acid and its butyl ester with amines was studied. Depending on the basicity and three-dimensional structure of the amines, the amidation of the ester group may be accompanied by cleavage of the pyrimidine ring at the 3,4-bond to form ureidosuccinic acid or its monoamide.

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Literature cited

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga

    D. Ya. Sniker, É. I. Stankevich & G. Ya. Dubur

Authors
  1. D. Ya. Sniker
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  2. É. I. Stankevich
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  3. G. Ya. Dubur
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Additional information

The reaction products have been previously described [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1141–1145, August, 1972.

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Sniker, D.Y., Stankevich, É.I. & Dubur, G.Y. 2,4-Dihydroxy-5,6-dihydropyrimidine derivatives. Chem Heterocycl Compd 8, 1032–1036 (1972). https://doi.org/10.1007/BF00476339

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  • DOI: https://doi.org/10.1007/BF00476339

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