Synthesis and some transformations of pyrroles with aliphatic acyl substituents
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A number of higher aliphatic pyrryl ketones were synthesized. It is shown that a carbethoxy group in the 5 position of the pyrrole ring relatively weakly deactivates the 3 position of the ring to electrophilic attack during Friedel—Crafts acylation but hinders this reaction considerably when it is in the adjacent 4 position. The oxidation of the α-methyl group in a series of pyrryl ketones and the corresponding alcohols was studied.
KeywordsOxidation Alcohol Organic Chemistry Ketone Pyrrole
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