Chemistry of Heterocyclic Compounds

, Volume 9, Issue 1, pp 13–17 | Cite as

New method for the synthesis of macrocyclic compounds

XV. Alkylation of 2-carbethoxy-α-cyclo-1-thienones
  • S. Z. Taits
  • V. N. Bulgakova
  • Ya. L. Gol'dfarb


A method was developed for the preparation of macrocyclic 2-alkylcycloalkanones by alkylation of 2-carbethoxy-α-cyclothienones with subsequent desulfurization and ketone cleavage. Only C-alkylation occurs under the described conditions (potassium metal in hexamethylphosphoric triamide, sodium hydride in dioxane).


Sodium Potassium Organic Chemistry Ketone Hydride 
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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1975

Authors and Affiliations

  • S. Z. Taits
    • 1
  • V. N. Bulgakova
    • 1
  • Ya. L. Gol'dfarb
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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