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Chemistry of Heterocyclic Compounds

, Volume 9, Issue 1, pp 13–17 | Cite as

New method for the synthesis of macrocyclic compounds

XV. Alkylation of 2-carbethoxy-α-cyclo-1-thienones
  • S. Z. Taits
  • V. N. Bulgakova
  • Ya. L. Gol'dfarb
Article

Abstract

A method was developed for the preparation of macrocyclic 2-alkylcycloalkanones by alkylation of 2-carbethoxy-α-cyclothienones with subsequent desulfurization and ketone cleavage. Only C-alkylation occurs under the described conditions (potassium metal in hexamethylphosphoric triamide, sodium hydride in dioxane).

Keywords

Sodium Potassium Organic Chemistry Ketone Hydride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1975

Authors and Affiliations

  • S. Z. Taits
    • 1
  • V. N. Bulgakova
    • 1
  • Ya. L. Gol'dfarb
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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