Abstract
The rate constants for cyclization of N,N-dimethyl-N′-(α-cyano-β-dimethylamino)-crotonylformamidine and its five-, six-, and seven-membered analogs and N-methyl-2-[N-(α-cyano-β-dimethylamino) acryloylimino]piperidine to derivatives of 2-pyridone, pyrrolo-, and pyrido-, and azepino[3,2-c]pyridine and 1,8-naphthyridine were measured in dimethylformamide (DMF) at 120–150 deg C. It is assumed that a new C-C bond with a change in the hybridization of the C(3) atom from sp2 to sp3 develops in the rate-determining step.
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See [1] for communication XXII.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1523–1526, November, 1977.
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Granik, V.G., Grigor'ev, A.B. & Polievktov, M.K. Acetals of lactams and acid amides. Chem Heterocycl Compd 13, 1217–1220 (1977). https://doi.org/10.1007/BF00475950
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DOI: https://doi.org/10.1007/BF00475950