Abstract
A method is proposed for the synthesis of 5-acylamino-2,3-dimethylthiophene-4-carbaldehydes and 5-acylamino-2,3-tetramethylenethiophene-4-carbaldehydes by the formylation of the corresponding thiophenes using the Vilsmeier reaction. From the formyl derivatives obtained, previously unaccessible derivatives of thieno[2,3-b]pyridine, thieno[2,3-d]pyrimidine, and thieno[3′,2′∶5,6]pyrido[2,3-d]-pyrimidine have been synthesized.
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V. I. Shvedov, V. K. Vasil'eva, Yu. I. Trofimkin, and A. N. Grinev, Khim. Geterotsikl. Soedin., 1628 (1973).
V. I. Shvedov, I. A. Kharizomenova, and A. N. Grinev, Khim. Geterotsikl. Soedin., 1624 (1973).
A. Bishler and M. Lang, Ber., 28, 279 (1895).
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For Communication VIII, see [1].
Translated from Khimiya Geterotsildicheskikh Soedinenii, No. 1, pp. 58–60, January, 1974.
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Shvedov, V.I., Kharizomenova, I.A. & Grinev, A.N. Functional derivatives of thiophene. Chem Heterocycl Compd 10, 50–52 (1974). https://doi.org/10.1007/BF00475907
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DOI: https://doi.org/10.1007/BF00475907