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Synthesis and properties of analogs of pyridoxal

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A method for the synthesis of analogs of pyridoxal-2-norpyridoxal, 6-methyl-2, 4-pyridoxal, and 6-methylpyridoxal—has been worked out. The reaction of 5-ethoxyoxazoles with maleic diesters gave diesters of substituted 3-hydroxycinchomeric acids, which were converted by reduction with lithium aluminum hydride into analogs of pyridoxine. The latter were oxidized with magnesium dioxide to the corresponding analogs of pyridoxal. The oximes of the aldehydes and their Schiff's bases with p-phenetidine have been obtained. Analogs of pyridoxamine have been obtained by the hydrogenation of the oximes. The UV absorption spectra of the compounds and the ratios of the ionic forms in aqueous solutions have been studied.

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Authors and Affiliations

  1. Institute of Molecular Biology AS USSR, USSR

    V. L. Florent'ev, N. A. Drobinskaya, L. V. Ionova & M. Ya. Karpeiskii

  2. Second Moscow Medical Institute, USSR

    V. L. Florent'ev, N. A. Drobinskaya, L. V. Ionova & M. Ya. Karpeiskii

Authors
  1. V. L. Florent'ev
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  2. N. A. Drobinskaya
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  3. L. V. Ionova
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  4. M. Ya. Karpeiskii
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Florent'ev, V.L., Drobinskaya, N.A., Ionova, L.V. et al. Synthesis and properties of analogs of pyridoxal. Chem Heterocycl Compd 5, 774–781 (1972). https://doi.org/10.1007/BF00475854

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  • DOI: https://doi.org/10.1007/BF00475854

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