Chemistry of Heterocyclic Compounds

, Volume 7, Issue 7, pp 866–868 | Cite as

Mechanism of the formation of 2-aminothiazole in the reaction of chloroacetaldehyde with thiourea

  • B. G. Yasnitskii
  • E. B. Dol'berg


The kinetics of the reaction of chloroacetaldehyde with thiourea in water at the C=O and C-Cl bonds were studied. The first step of the formation of the 2-aminothiazole is the reaction of the NH2 group of thiourea with the C=O group of chloroacetaldehyde. Hydrogen chloride evolution and the formation of a thiazole ring are secondary processes that occur simultaneously.


Hydrogen Chloride Organic Chemistry Thiourea Thiazole 
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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1974

Authors and Affiliations

  • B. G. Yasnitskii
    • 1
  • E. B. Dol'berg
    • 1
  1. 1.Kharkov Scientific-Research Pharmaceutical-Chemistry InstituteUSSR

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