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Chemistry of Heterocyclic Compounds

, Volume 7, Issue 7, pp 866–868 | Cite as

Mechanism of the formation of 2-aminothiazole in the reaction of chloroacetaldehyde with thiourea

  • B. G. Yasnitskii
  • E. B. Dol'berg
Article

Abstract

The kinetics of the reaction of chloroacetaldehyde with thiourea in water at the C=O and C-Cl bonds were studied. The first step of the formation of the 2-aminothiazole is the reaction of the NH2 group of thiourea with the C=O group of chloroacetaldehyde. Hydrogen chloride evolution and the formation of a thiazole ring are secondary processes that occur simultaneously.

Keywords

Hydrogen Chloride Organic Chemistry Thiourea Thiazole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1974

Authors and Affiliations

  • B. G. Yasnitskii
    • 1
  • E. B. Dol'berg
    • 1
  1. 1.Kharkov Scientific-Research Pharmaceutical-Chemistry InstituteUSSR

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