Abstract
Dimorpholinoacetic acid morpholide was used as an aldehyde in the Hantzsch synthesis, and the morpholides of the corresponding 1,4-dihydroisonicotinic acid derivatives were obtained. The direct esterification of the morpholides of the 1,4-dihydroisonicotinic acid derivatives gave their methyl, ethyl, and isopropyl esters. The oxidation of 2,6-dimethyl-3,5-dicarbethoxy-l, 4-dihydroisonicotinic acid and its morpholide with sodium nitrite occurs with cleavage, while the oxidation of the methyl esters takes place with retention of the γ substituent. The morpholide of 10,12-dioxo-5,10,11,12-tetrahydrodiindeno[1,2-b;2',1'-e]pyridinecarboxylic acid is oxidized with retention of the γ substituent.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 354–356, March, 1972.