Abstract
On the basis of a comparison of the protolysis constants and vibrational frequencies it is shown that intermolecular interactions are present in 6-substituted 9-(α,Ω-dihydroxyalkyl)-purines and the corresponding mono- and diphosphates. In addition, in the case of the phosphates the existence of intramolecular interactions of electrostatic character between the phosphate group and the heteroring is also proposed. A comparison of the protolysis constants provides evidence for the different character of the interaction of the dihydroxyalkyl residue with the heteroring of the base in series of adenine and hypoxanthine derivatives.
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See [1] for communication II.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1684–1689, December, 1974.
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Giller, S.A., Goncharova, I.N., Getsova, I.N. et al. Analogs of purine nucleosides and purine mono- and polynucleotides. Chem Heterocycl Compd 10, 1481–1485 (1974). https://doi.org/10.1007/BF00474335
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DOI: https://doi.org/10.1007/BF00474335