Abstract
A method was developed for the synthesis of 5- or 6-formylindoles by reaction of 5- or 6-aminomethylindoles with hexamethylenetetramine in acidic media. 1-Methyl-7-formylindole was obtained by recyclization of nicotyrine methiodide under the influence of alkaline agents. The corresponding vinylindoles were obtained by condensation of formylindoles with nitromethane, nitroethane, and malonic acid. The structures of the products were proved by alternative synthesis, the results of elementary analysis, and the UV, IR, PMR, and mass spectra.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 338–343, March, 1979.
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Yudin, L.G., Kost, A.N., Muminov, A. et al. Synthesis and reactions of benzoformylindoles. Chem Heterocycl Compd 15, 276–281 (1979). https://doi.org/10.1007/BF00474091
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DOI: https://doi.org/10.1007/BF00474091