Abstract
Chloropyrimidines react readily with the sodium salts of alkyl aryl ketoximes to give acetophenone O-(2,4-dimethylpyrimidin-6-yl)- and O-(4,6-dimethylpyrimidin-2-yl)oximes, the oximino-groups in which readily undergo nucleophilic substitution.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. P. Mamaev, O. A. Zagulyaeva, and S. M. Shein, Khim. Geterotsikl. Soedin., No. 6, 723 (1973).
Kh. Van Der Plas (H. C. Van der Plas), Khim. Geterotsikl. Soedin., No. 8, 1011 (1987).
D. J. Brown, The Pyrimidines, Interscience, New York-London (1962), p. 162.
N. B. Chapman and D. Q. Russel-Hill, J. Chem. Soc., No. 11, 1563 (1956).
K. Shirakawa, Yakugaku Zasshi, 79, 1477 (1959); Chem. Abstr., 54, 11038 (1960).
P. B. Terentiev, A. N. Kost, and J. Lange, J. Org. Mass Spectrom., 9, 1022 (1974).
J. D. Hennion and D. G. J. Kingston, Org. Mass Spectrom., 13, 431 (1978).
G. G. Danagulyan, N. G. Balasanyan, and M. G. Zalinyan, Khim. Geterotsikl. Soedin., No. 4, 563 (1988).
A. N. Kost, R. S. Sagitullin, and G. G. Danagulyan, Khim. Geterotsikl. Soedin., No. 5, 606 (1976).
A. N. Kost, R. S. Sagitullin, and G. G. Danagulyan, Khim. Geterotsikl. Soedin., No. 10, 1400 (1978).
H. C. Van der Plas and H. Yongejan, Rec. Trav. Chim., 89, 680 (1970).
F. Baumbach, H. G. Henning, and G. Hilgetag, Z. Chem., 4, 67 (1964).
D. J. Brown and J. A. Hoskins, J. Chem. Soc., Perkin I, No. 2, 522 (1972).
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1644–1648, December, 1989.
Rights and permissions
About this article
Cite this article
Danagulyan, G.G., Balasanyan, N.G., Terent'ev, P.B. et al. Synthesis of substituted methyl aryl ketone pyrimidinyloximes and their reactions with nucleophiles. Chem Heterocycl Compd 25, 1369–1373 (1989). https://doi.org/10.1007/BF00473866
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00473866