Abstract
Cyclization of formylated and acetylated α-substituted 2-aminomethylbenzothiazoles with phosphorus oxychloride gives 3-substituted imidazo [5, 1-b] benzothiazoles, and 3-substituted 1-methylimidazo [5, 1-b] benzothiazoles. Treatment of 2-benzothiazolyl-4-pyridylaminomethane with formic acid gives 3-(4-pyridyl) imidazo [5, 1-b] benzothiazole. 1-Mercapto-3-phenylimidazo [5, 1-b] benzothiazole is converted into 3-phenylimidazo [5, 1-b] benzothiazole by elimination of the mercapto group.
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References
V. V. Avidon and M. N. Shchukina, KhGS, 64, 1965.
V. V. Avidon and M. N. Shchukina, ZhOKh, 34, 2969, 1964.
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Avidon, V.V., Shchukina, M.N. Synthesis of some substituted imidazo [5, 1-b] benzothiazoles. Chem Heterocycl Compd 1, 229–232 (1966). https://doi.org/10.1007/BF00473596
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DOI: https://doi.org/10.1007/BF00473596