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Acyclic analogs of nucleosides. Synthesis of hydroxyalkylbenzimidazoles and -benzotriazoles

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Abstract

Condensation of trimethylsilyl derivatives of benzimidazole and benzotriazole with alkylating agents in the presence of trimethylsilyl trifluoromethanesulfonate or SnCl4, or direct alkylation of the sodium salts of benzimidazole and benzotriazole, gives 1-(2,3-dihydroxypropyl)-, 1-(3-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, and 1-(1,5-dihydroxy-3-oxapent-2-yl)benzimidazole and -benzotriazole.

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Authors and Affiliations

  1. Svchenko Kiev State University, 252017, Kiev

    A. É. Yavorskii, A. V. Stetsenko, S. G. Zavgorodnii & V. L. Florent'ev

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  1. A. É. Yavorskii
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  2. A. V. Stetsenko
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  3. S. G. Zavgorodnii
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  4. V. L. Florent'ev
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 198–202, February, 1988.

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Yavorskii, A.É., Stetsenko, A.V., Zavgorodnii, S.G. et al. Acyclic analogs of nucleosides. Synthesis of hydroxyalkylbenzimidazoles and -benzotriazoles. Chem Heterocycl Compd 24, 163–167 (1988). https://doi.org/10.1007/BF00473325

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  • DOI: https://doi.org/10.1007/BF00473325

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