Abstract
The alkylation of benzofuran with tert-butyl chloride in various solvents with a zinc chloride catalyst was studied. It was found that the alkylation proceeds primarily at the 3-position. The ratio of the 2- and 3-tert-butylbenzofurans is ∼ 1∶2 regardless of the nature of the solvent.
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R. D. Brown and B. W. Coller, Austral. J. Chem., 12, 152 (1959).
N. P. Buu-Hoi, N. D. Xuong, and N. V. Bac, J. Chem. Soc., 173 (1964).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 156–159, February, 1971.
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Karakhanov, É.A., Drovyannikova, G.V. & Viktorova, E.A. Catalytic alkylation of benzofurans. Chem Heterocycl Compd 7, 144–146 (1971). https://doi.org/10.1007/BF00473070
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DOI: https://doi.org/10.1007/BF00473070