1, 2, 5-Trimethyl-4-phenylethynylpiperidol-4 and its reactions

Abstract

1, 2, 5-Trimethyl-4-phenylethynylpiperidol-4 and 1 2, 5-trirnethyl-4-ß-phenylethynylpiperidol-4 are prepared by various methods. Their interconversion is studied, and individual stereoisomeric forms of these piperidols isolated. 1, 2, 5-Trimethyl-4-phenylethynylpiperidol-4 is hydrated, and the resultant ω -(1,′ 2′, 5′-trimethyldidehydropiperidyl-4′) acetophenone used to effect synthesis of a number of secondary and tertiary carbinols. 2, 5-Dimethyl-4-ß-phenylethylpyridine is prepared from 1, 2, 5-trimethyl-4-ß-phenylethylpiperidol-4.