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Chlorination of 2,6-dimethyl-3,5-dicarbomethoxy-4-(2′-difluoromethoxyphenyl)-1,4-dihydropyridine (phoridone)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Chlorination of 2,6-dimethyl-3,5-dicarbomethoxy-4-(2′-difluoromethoxyphenyl)-1,4-dihydropyridine gives 2,3,4,5-tetrahydropyridines with different degrees of chlorination dependent upon the quantitative ratio of reagents. The reaction proceeds without oxidation of the dihydropyridine ring.

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Literature Cited

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Authors and Affiliations

  1. Organic Synthesis Institute, Academy of Sciences of the Latvian SSR, 226006, Riga

    I. P. Skrastin'sh, V. V. Kastron, É. É. Liepin'sh, I. B. Mazheika, R. O. Vitolinya & G. Ya. Dubur

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  1. I. P. Skrastin'sh
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  2. V. V. Kastron
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  3. É. É. Liepin'sh
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  4. I. B. Mazheika
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  5. R. O. Vitolinya
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  6. G. Ya. Dubur
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 376–379, March, 1990.

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Skrastin'sh, I.P., Kastron, V.V., Liepin'sh, É.É. et al. Chlorination of 2,6-dimethyl-3,5-dicarbomethoxy-4-(2′-difluoromethoxyphenyl)-1,4-dihydropyridine (phoridone). Chem Heterocycl Compd 26, 323–325 (1990). https://doi.org/10.1007/BF00472554

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  • DOI: https://doi.org/10.1007/BF00472554

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