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Chemistry of Heterocyclic Compounds

, Volume 27, Issue 6, pp 651–656 | Cite as

Rearrangements of 1-oxa-2-azoles. 4. Synthesis and rearrangement of isoxazole- and 4,5-dihydroisoxazole-3-carboxylic acid amidoximes

  • V. G. Andrianov
  • V. G. Semenikhina
  • A. V. Eremeev
Article

Abstract

Isoxazole- and 4,5-dihydroisoxazole-3-carboxylic acid amidoximes were obtained in the reaction of 5-trifluoromethyl-1,2,4-oxadiazole-3-carbohydroximic acid bromide in the presence of sodium bicarbonate with monosubstituted ethylenes and acetylenes with subsequent opening of the oxadiazole ring. Amidoximes of the isoxazole series undergo rearrangement to aminofurazans under the influence of alkalis.

Keywords

Sodium Ethylene Bromide Organic Chemistry Bicarbonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • V. G. Andrianov
    • 1
  • V. G. Semenikhina
    • 1
  • A. V. Eremeev
    • 1
  1. 1.Institute of Organic SynthesisLatvian Academy of SciencesRiga

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