Abstract
The action of n-butyllithium on benzo[b]-1,4-diazabicyclo[2.2.2]octene leads to lithiation in the 3′ position of the aromatic ring. The reaction of this lithium derivative with electrophilic reagents was used to synthesize 3′- and 3′,6′-substituted derivatives of benzo[b]-1,4-diazabicyclo[2.2.2]octene.
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See [1] for Communication 20.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 798–803, June, 1991.
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Gall', A.A., Trachum, A.S., Romantsev, V.A. et al. Diazabicycloalkanes with nitrogen atoms in the nodal positions. 21. Heteroatom-promoted lithiation of benzo[b]-1,4-diazabicyclo[2.2.2]octene and introduction of substituents into the annelated benzene ring. Chem Heterocycl Compd 27, 626–630 (1991). https://doi.org/10.1007/BF00472513
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DOI: https://doi.org/10.1007/BF00472513