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Chemistry of Heterocyclic Compounds

, Volume 27, Issue 6, pp 590–594 | Cite as

Lactam and acid amide acetals 68. 1-Cyanomethyl-2-pyrrolidone diethylacetal in the synthesis of 7,8-trimethylenepurine derivatives

  • E. N. Dozorova
  • A. V. Kadushkin
  • G. A. Bogdanova
  • N. P. Solov'eva
  • V. G. Granik
Article

Abstract

1-Cyanomethyl-2-cyaniminopyrrolidine was synthesized by the reaction of 1-cyanomethyl-2-pyrrolidone diethylacetal with cyanamide. The product undergoes Thorpe—Ziegler cyclization under the influence of sodium ethoxide to give 2-amino-3-cyano-5,6-dihydro-7H-pyrrolo[1,2-a]imidazole, from which 4-amino derivatives of pyrrolo[2,1-f]purine were synthesized.

Keywords

Sodium Acetal Organic Chemistry Amide Imidazole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • E. N. Dozorova
    • 1
  • A. V. Kadushkin
    • 1
  • G. A. Bogdanova
    • 1
  • N. P. Solov'eva
    • 1
  • V. G. Granik
    • 1
  1. 1.Center for the Chemistry of MedicinalsS. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical ChemistryMoscow

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