Chemistry of Heterocyclic Compounds

, Volume 10, Issue 3, pp 324–326 | Cite as

Synthesis in the phenothiazine series

XXXVI. Quaternary salts of imidazo[4,5,1-k,l]phenothiazine and their transformations
  • Z. I. Ermakova
  • A. N. Gritsenko
  • S. V. Zhuravlev


Quaternary salts of imidazo[4,5,1-k,l]phenothiazine were reduced with potassium borohydride to 1,2-dihydro-2-methylimidazo[4,5,1-k,l]phenothiazine, which was converted to 1,2 dihydro-2-methylimidazo[4,5,1-k,l]phenothiazine-1-thione and 1-methylamino-10-formylphenothiazine. The latter was hydrolyzed to 1-methylaminophenothiazine, which was also obtained by reduction of methyl phenothiazine-1-carbamate. The PMR and IR spectra of some of the derivatives are discussed.


Methyl Potassium Organic Chemistry Borohydride Phenothiazine 
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Literature cited

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    Z. I. Ermakova, A. N. Gritsenko, and S. V. Zhuravlev, Khim. Geterotsikl. Soedin., 202 (1974).Google Scholar
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    A. N. Gritsenko, Z. I. Ermakova, V. S. Troitskaya, and S. V. Zhuravlev, Khim. Geterotsikl. Soedin., 767 (1971).Google Scholar
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    A. V. El'tsov, Zh. Organ. Khim., 3, 199 (1967).Google Scholar
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    S. V. Zhuravlev, A. N. Gritsenko, and Z. I. Ermakova, Khim. Geterotsikl. Soedin., No. 3, 235 (1971).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Z. I. Ermakova
    • 1
  • A. N. Gritsenko
    • 1
  • S. V. Zhuravlev
    • 1
  1. 1.Institute of PharmacologyAcademy of Medical Sciences of the USSRMoscow

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