Chemistry of Heterocyclic Compounds

, Volume 10, Issue 3, pp 310–312 | Cite as

Synthesis of substituted 2-amino-5,6-dihydro-4H-1,3-thiazines and 2-iminotetrahydro-1,3-thiazines

  • P. L. Ovechkin
  • L. A. Ignatova
  • A. E. Gekhman
  • B. V. Unkovskii


N-Aryl-N′-(2-methyl-4-hydroxy-2-pentyl)thioureas are cyclized in acidic media to 4,4,6-trimethyl-2-arylimino-5,6-dihydro-4H-1,3-thiazines, the methylation of which with methyl iodide gives 4,4,6-trimethyl-2-methylarylamino-5,6-dihydro-4H-1,3-thiazines. 3,4,4,6-Tetramethyl-2-aryliminotetrahydro-1,3-thiazines were synthesized by cyclization of Naryl-N′-methyl-N′-(2-methyl-4-hydroxy-2-pentyl)thioureas.


Methyl Organic Chemistry Iodide Thiourea Acidic Medium 
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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • P. L. Ovechkin
    • 1
  • L. A. Ignatova
    • 1
  • A. E. Gekhman
    • 1
  • B. V. Unkovskii
    • 1
  1. 1.M. V. Lomonosov Moscow Institute of Fine Chemical TechnologyUSSR

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