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Chemistry of Heterocyclic Compounds

, Volume 10, Issue 3, pp 310–312 | Cite as

Synthesis of substituted 2-amino-5,6-dihydro-4H-1,3-thiazines and 2-iminotetrahydro-1,3-thiazines

  • P. L. Ovechkin
  • L. A. Ignatova
  • A. E. Gekhman
  • B. V. Unkovskii
Article
  • 34 Downloads

Abstract

N-Aryl-N′-(2-methyl-4-hydroxy-2-pentyl)thioureas are cyclized in acidic media to 4,4,6-trimethyl-2-arylimino-5,6-dihydro-4H-1,3-thiazines, the methylation of which with methyl iodide gives 4,4,6-trimethyl-2-methylarylamino-5,6-dihydro-4H-1,3-thiazines. 3,4,4,6-Tetramethyl-2-aryliminotetrahydro-1,3-thiazines were synthesized by cyclization of Naryl-N′-methyl-N′-(2-methyl-4-hydroxy-2-pentyl)thioureas.

Keywords

Methyl Organic Chemistry Iodide Thiourea Acidic Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

  1. 1.
    M. Tisler, Arch. Pharm., 293, 621 (1960).Google Scholar
  2. 2.
    H. Najer, R. Giudicelli, and J. Menin, Bull. Soc. Chim. France, 2120 (1965).Google Scholar
  3. 3.
    E, Cherbuliez, B. Baehler, O. Espeio, H. Jindra, B. Willhalm, and J. Rabinowitz, Helv. Chim. Acta, 50, 331 (1967).Google Scholar
  4. 4.
    L. Toldy, P. Sohar, K. Farago, Z. Toth, and L. Bartalits, Tetrahedron Lett., 2167 (1970).Google Scholar
  5. 5.
    L. A. Ignatova, P. L. Ovechkin, M. Z. Branzburg, A. E. Gekhman, and B. V. Unkovskii, Khim. Geterotsikl. Soedin., 1037 (1972).Google Scholar
  6. 6.
    M. Janssen, Spectrochim. Acta, 17, 475 (1961).Google Scholar
  7. 7.
    W. Kutzelnigg and R. Mecke, Spectrochim. Acta, 17, 530 (1961).Google Scholar
  8. 8.
    L. A. Ignatova, A. E. Gekhman, P. L. Ovechkin, and B. V. Unkovskii, Khim. Geterotsikl. Soedin., 354 (1974).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • P. L. Ovechkin
    • 1
  • L. A. Ignatova
    • 1
  • A. E. Gekhman
    • 1
  • B. V. Unkovskii
    • 1
  1. 1.M. V. Lomonosov Moscow Institute of Fine Chemical TechnologyUSSR

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